A rise in tissue temperature is significant when it exceeds:

A rise in tissue temperature is significant when it exceeds 2°C. This threshold is important in medical diagnostics and therapeutic practices, as even a small increase in temperature can have physiological effects on the tissues.

When the temperature rises beyond this level, it can indicate potential damage to the cells and tissues being imaged or treated. Research has shown that increasing the temperature by 2°C can alter cellular metabolism and may lead to adverse effects, such as increased perfusion, cellular damage, or thermal injury.

In contrast, increases of 1°C are generally not considered significant in most clinical scenarios, as the body can often compensate for minor fluctuations in temperature without detrimental effects. Higher increases, such as 5°C or 9°C, would typically be associated with more severe tissue concerns and are considered thresholds for possible thermal damage or injury. Thus, the 2°C threshold serves as a critical point of reference in clinical and diagnostic settings.